Postdoctoral Researcher
Label-free characterization of hydrated, low-concentration biological samples is critical to support
regenerative medicine applications such as cell and gene therapies. NIST has developed a high-
sensitivity infrared (IR) spectroscopy technique and demonstrated it for protein solutions. This
technique will enable the characterization of a protein solution with a high sensitivity with a frequency
range from 970 cm -1 to 1840 cm -1 . This project will focus on advancing the applicability of the spectroscopy
technique by improving its concentration sensitivity and applying it to characterize gene delivery
systems and other biological molecules.
Development of High-Sensitivity IR Spectroscopy for Proteins and Gene Delivery Systems
- A Ph.D. degree in Chemistry, Physics, Pharmaceutical Science, Manufacturing, or a related field.
- Familiarity with IR spectroscopy and analytical chemistry is preferred.
- Familiarity with gene delivery is also desired.
- Ability to analyze chemical and spectral data.
- Strong oral and written communication skills.
- Develop the instrumentation and analysis protocol for high-sensitivity IR spectroscopy.
- Analyze IR spectra of proteins and gene delivery systems.
- Discuss with NIST staff on the progress and the results.
- Present results at internal meetings, and occasional meetings with external stakeholders.
- Write papers based on the results of method development and produced data.